Dr. Tyler A. Zimmerman

Research Activities and Interests:

Bioanalytical chemistry and bioinformatics.

Tyler’s research supports the mass spectral libraries of the Mass Spectrometry Data Center Group. His current research is the integration of prior probability knowledge into mass spectral library searching algorithms and other computation-based projects.

Traditionally, his research achieved the synthesis of computation with experimental design. On the computational side, past activities included the development of new statistical methods in the Laboratory for Chemometrics (University of Delaware) and the development of the widely-used NeuroPred software at the NIDA Center’s Bioinformatics & Systems Biology Core (University of Illinois). On the experimental side, his past work included the mass spectrometric imaging of tissue sections (Universities of Illinois & Liege), the high mass accuracy measurement of human antibody glycans in the context of HIV (Northwestern University), and the quantification of protein levels in human serum using QconCAT strategies (NIST Gaithersburg).

Tyler is interested in a wide variety of projects that involve computation and experimental design. He is an author on at least 14 peer-reviewed publications.

Awards: European Degree Equivalency, Ph.D. to “Docteur en Sciences” (2011) Hypercube Scholar Award, Hypercube, Inc. (2005) Membership and Professional Activities: American Society for Mass Spectrometry (ASMS)


Research Chemist

Biomolecular Measurement Division

Mass Spectrometry Data Center

Employment History:

Research Chemist, NIST, 2014-Present

Research Scientist, Northwestern University, 2013-2014

NRC Postdoctoral Research Associate, Bioanalytical Science Group, NIST, 2012-2013

FNRS Postdoctoral Fellow (Chargé de Recherches), University of Liège, Belgium, 2010-2012


Ph.D., Analytical Chemistry, University of Illinois at Urbana-Champaign, 2010

B.S., Chemistry, University of Delaware, 2005

Contact Phone: 301-975-2017

Email: tyler.zimmerman@nist.gov

Fax: 301-975-2643

Selected Publications: Quantification of transferrin in human serum using both QconCAT and synthetic internal standards http://www.nist.gov/manuscript-publication-search.cfm?pub_id=914041