==== The NISTmAb Mass Spectral Library of Human IgG1κ mAb Drugs ====

A mass spectral library composed of all identifiable spectra derived from the tryptic digest of the NISTmAb IgG1κ were created from over six million peptide-spectrum matches acquired by high-resolution, accurate-mass 1D/2D LC-MS/MS analyses. The library contains a selection of 12,600 high quality HCD spectra of 3,300 peptide ions. \\ 


//Reference: MAbs. 2018 Apr;10(3):354-369. The NISTmAb tryptic peptide spectral library for monoclonal antibody characterization. Dong Q, Liang Y, Yan X, Markey SP, Mirokhin YA, Tchekhovskoi DV, Bukhari TH, Stein SE.//



^ ^File ^Size ^Link to download |
|1| **NISTmAb_v20190711_mssearch.zip** - Archive with Library in NIST MS Search format. For the program itself see **Notes<sup>*</sup>** section below.  |~48MB |[[https://chemdata.nist.gov/download/peptide_library/libraries/nistmab/NISTmAb_v20190711_mssearch.zip|Download]] |
|2| **NISTmAb_v20190711_msp.zip** - Archive for Installation of Windows Database Program and Library. Download archive and unzip installation file. Run **NISTmAb_Mass_Spectral_Library.exe** to install the search program and database  |~19MB |[[https://chemdata.nist.gov/download/peptide_library/libraries/nistmab/NISTmAb_v20190711_msp.zip|Download]] |
|3| md5_checklist.chk - MD5 hash file.  | 1KB |[[https://chemdata.nist.gov/download/peptide_library/libraries/nistmab/md5_checklist.chk|Download]] |


__**Notes**__
  - NIST MS Search program with previous (2018) version of the library still available for [[https://chemdata.nist.gov/download/peptide_library/libraries/nistmab/NISTmAb_Mass_Spectral_Library.zip|download]] (65MB). Download archive and unzip installation file. Run executable for installation of the program and the library. Newer version of the library can be copied over the old one. 
  - Little bit more information about the program is in the [[https://chemdata.nist.gov/download/peptide_library/libraries/nistmab/Readme.pdf|**Readme.pdf**]] file.

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