Research Chemist
NIST Mass Spectrometry Data Center
Biomolecular Measurement Division

100 Bureau Drive MS-8362 Gaithersburg, MD 20899
Phone: (301)-975-6731
Email: lorna.deleoz@nist.gov
Fax: (301)-975-2643

Dr. De Leoz aims to extend the scope of the NIST mass spectral reference library to include glycans and glycopeptides. Her work involves improving the characterization of glycoforms through the development of new mass spectrometry protocols, mass spectral reference data, and data analysis techniques. Dr. De Leoz comes from the University of California at Davis where she earned her Ph.D. in Chemistry. Her Ph.D. research was focused on using mass spectrometry for discovering glycan biomarkers for cancer and understanding the role of human milk oligosaccharides in infants. She has presented a number of talks and posters and her work has resulted in 16 publications and 800+ citations. Dr. De Leoz was named outstanding researcher twice and is a patent inventor on the synthesis of a drug. She has over eight years of industry experience in research and development in an ISO-accredited laboratory.

Dr. De Leoz brings in years of experience in mass spectrometry (MS, MS/MS and MSn analysis); liquid chromatography; characterization of therapeutic antibodies, including intact protein molecular weight measurements, glycan, glycopeptide, and peptide analyses; and method development using several analytical instruments.

• NIST Interlaboratory Study: Glycans from IgG
• NIST Glycan MS/MS Reference Library
• NIST Glyco Mass Calculator

• Research Chemist, NIST, 2013-present
• NIST-American Recovery and Reinvestment Act (ARRA) Post-Doctoral Fellow, NIST, 2011-2013
• Doctoral Researcher, University of California Davis, 2006-2011

Dr. De Leoz received her B.S. in Chemistry, B.S. in Computer Engineering, and M.S. in Chemistry degrees from Ateneo de Manila University; Ph.D. in Chemistry degree with Professor C.B. Lebrilla from University of California Davis; and the NIST American Recovery and Reinvestment Act Postdoctoral Fellowship through the University of Maryland.

1. NIST Interlaboratory Study on the Glycosylation of NISTmAb, a Monoclonal Antibody Reference Material
2. Human Milk Glycomics and Gut Microbial Genomics in Infant Feces Shows Correlation between Human Milk Oligosaccharides and Gut Microbiota: A Proof-of-Concept Study
3. Lacto-N-tetraose, fucosylation, and secretor status are highly variable in human milk oligosaccharides from women delivering preterm
4. High-mannose glycans are elevated during breast cancer progression
5. Glycomic approach for potential biomarkers on prostate cancer: profiling of N-linked glycans in human sera and pRNS cell lines

• California Separation Science Society (CASSS) Mass Spectrometry Travel Award, 2013.
• Young Investigator Award, Mass Spectrometry: Applications to the Clinical Laboratory (MSACL) Conference, San Diego, CA, 2013.
• Finalist, Bioanalysis Young Investigator Award, Future Science, London, UK, 2012.
• Most Outstanding Biotechnology Poster Presentation, NIST Sigma Xi Honor Society, 2012.
• US Human Proteome Organization (HUPO) Travel Award, 2012.
• Young Investigator Academic Award, MSACL Conference, San Diego, CA, 2011.
• Business Development Program Fellowship, University of California-Davis, 2010.
• People’s Choice Award, University of California Big Bang Business Plan Competition, 2010.
• International Youth Award, Federation of European Biochemical Societies, Glycomarkers for Disease Meeting, Mikolaju, Poland, 2010.
• Consortium for Women and Research Travel Award, University of California, Davis, CA, 2009.
• Outstanding Graduate Student Teaching Award, University of California-Davis, 2007.
• Award for Outstanding Thesis in Advanced Science and Technology, Department of Science and Technology, Philippines, 2005.
• Outstanding Graduate Research Award, Ateneo de Manila University, 2005.

• Sigma Xi Honor Society, NIST Chapter, President (2016-2017), Treasurer (2013-2016), Member (2012-present)
• American Society for Mass Spectrometry (ASMS), Publications Committee Member (2015-2017), Session Chair (2014), Member (2007-present)
• Washington Chromatography Discussion Group, VP and Program Chair (2017-present), Secretary (2016-2017)
• Philippine-American Academy of Science & Engineering, Member (2012-present)