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The IARPA Proteos Human Skin and Hair Library
Peptide Consensus HCD Spectral Library (Oct. 01, 2021)
This consensus spectral library was derived from 629 raw data files generated on Orbitrap mass spectrometers, which include
- 536 DDA and PRM raw data files for skin samples from the IARPA Proteos Program’s phases 1, 2, and 3. Data were generated by Signature Science and University of Washington using skin samples provided by Lawrence Livermore National Laboratory. Click here for more information on the IARPA Proteos Program.
- 19 DDA raw data files from LCMS analyses of Proteos skin samples at the Mass Spectrometry Data Center, NIST
- 74 DDA raw data files from LCMS analyses of human hair samples at the Mass Spectrometry Data Center, NIST
The library contains 27,971 consensus spectra that correspond to 20,131 distinct peptide sequences including 239 GVPs. The library was divided into three sub-libraries based on spectral quality score, number of miscleavages in a peptide sequence, and whether a peptide is tryptic or semi-tryptic.
| File - Description | Size | Link |
|---|---|---|
| Library 1 (best) NIST Library format: IARPA3_best_tissue_add_info.zip 8346 high-quality spectra, 6202 mostly tryptic peptides without missed cleavages. | 25MB | Download |
| Library 1 (best) MSP text format: IARPA3_best_tissue_add_info.msp.zip 8346 high-quality spectra, 6202 mostly tryptic peptides without missed cleavages. | 9.2MB | Download |
| Library 2 (good) NIST Library format: IARPA3_good_tissue_add_info.zip 9348 medium-quality spectra, 7503 mostly tryptic peptides with missed cleavages. | 29MB | Download |
| Library 2 (good) MSP text format: IARPA3_good_tissue_add_info.msp.zip 9348 medium-quality spectra, 7503 mostly tryptic peptides with missed cleavages. | 11MB | Download |
| Library 3 (semi-tryptic) NIST Library format: IARPA3_semitryptic_tissue_add_info.zip 10277 high- and medium-quality spectra, 7876 mostly semi-tryptic peptides. | 15MB | Download |
| Library 3 (semi-tryptic) MSP text format: IARPA3_semitryptic_tissue_add_info.msp.zip 10277 high- and medium-quality spectra, 7876 mostly semi-tryptic peptides. | 15MB | Download |
| SwissProt_human_20371_2021 ….. fasta.zip FASTA file used to create the library. | 7.3MB | Download |
| IARPA3_all.out.zip Text file listing the MS/MS scan numbers and associated raw data file names for each consensus spectrum in the library. | 12MB | Download |
| Library_GVP_list.tsv.zip Text file listing GVPs in the library that came from IARPA Proteos panels. | 2.2KB | Download |
| md5_checklist.chk - MD5 hash file. | 1KB | Download |
© Copyright information
These mass spectral libraries are protected by copyright law and may not be re-distributed without a valid Distribution Agreement. To receive such an agreement, contact the Standard Reference Data Program at the National Institute of Standards and Technology by emailing data@nist.gov or calling 301-975-2008.
