AMDIS - Automated Mass spectral Deconvolution and Identification System

AMDIS was developed as a tool to specifically allow gas-chromatography with mass spectral analysis (GC/MS) to be performed during confidential inspections under the Chemical Weapons Convention. It’s real value for most users in automating the complex process of extracting data from GC/MS data file.

How does this work

AMDIS works by finding all of the ions that rise and fall at the same time and associating them with a single component. Once it has found this component it compares it to a library of spectra and retention indices that you have provided.

This is what a single component might look like when a larger component is eluting at the same time. In this case the ion at m/z 83 does not have the same shape or time of maximization of the ions at m/z 111 and 158. Thus the ions at 111 and 158 are considered part of the component and the ion at 83 is not. Notice that in this case the TIC (shown in white) doe not even indicate that there should be a component at ~9.36 minutes.

How can you get AMDIS

AMDIS is provided as a part of both the full NIST MS Database package as well as the demo NIST database. AMDIS can make use of the NIST database software if it is present, but it does not require the database software. In addition AMDIS can be downloaded as a stand-alone program:

Further discussions of AMDIS are available here:

chemdata/amdis.txt · Last modified: 2023/10/11 16:13 (external edit)

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